1 Major progress was made by identification of susceptibility genes for schizophrenia. Relatively little is known about the pathology of schizophrenia, except for the strong evidence linking an overactive dopaminergic activity to the positive symptoms.
For the past decade, there has been enormous progress in understanding the neurobiology of schizophrenia. Although the etiology of schizophrenia is poorly understood, accumulating evidence reveals a wide range of brain abnormalities. 14 Brain structural abnormalities have been found in postmortem studies and in living subjects by computed tomography and magnetic resonance imaging. 2 Although causality is hard to prove, these genetic factors have shed light on specific biological cascades that are linked to the pathology of the disease.
Pathology of Schizophrenia synonyms, Pathology of Schizophrenia pronunciation, Pathology of Schizophrenia translation, English dictionary definition of Pathology of Schizophrenia. ) With respect to the negative and cognitive symptoms, more and more research now points to a failure in the normal communication between brain regions, generally referred to as the dysconnection hypothesis. schizophrenia (skĭt'səfrē`nēə), group of severe mental disorders characterized by reality distortions resulting in unusual thought patterns and behaviors.Because there is often little or no logical relationship between the thoughts and feelings of a person with schizophrenia, the disorder has often been called "split personality." Posted on Dec 5, 2013 in Knowledge | Comments Off on The Pathophysiology of Schizophrenia. Schizophrenia Definition Schizophrenia is a psychotic disorder (or a group of disorders) marked by severely impaired thinking, emotions, and behaviors. Schizophrenic patients are typically unable to filter sensory stimuli and may have enhanced perceptions of sounds, colors, and other features of their environment. The fact that the disorder is so symptomatically dynamic is one of the main reasons it is considered one of the most complex degenerative brain disorders in existence. n. 1. Pathology. Schizophrenia is a physiological phenomenon. The Pathophysiology of Schizophrenia.